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KMID : 0370220160600010021
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Yakhak Hoeji
2016 Volume.60 No. 1 p.21 ~ p.28
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Effect of Baicalin on the Ex vivo Production of Cytokines in Pristane-Induced Lupus Mice
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채병숙:Chae Byeong-Suk
저자없음:No authors listed
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Abstract
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Systemic lupus erythematosus (SLE) is characterized by dysregulatory production of proinflammatory cytokines and helper T (Th) cytokine-dependent autoantibody production. This study aims to investigate the protective effect of baicalin on the dysregulatory production of proinflammatory cytokines and Th cytokines in pristane-induced lupus mice. Mice were received i.p. a single injection of 0.5 ml of pristane, and then, later about 3 months, were used as a pristaneinduced lupus model. The pristane-induced lupus mice were administrated orally with baicalin 50 mg/kg once in a day for 10 days. Immune cells obtained from the pristane-primed lupus control group (lupus control) and baicalin-treated pristaneprimed lupus mouse group (BAC lupus) were cultured for 24 h or 36 h with/without mitogens. These results demonstrated that LPS-induced production of macrophage and splenic TNF-α and Con A-induced production of thymic IFN-γ were attenuated in BAC lupus compared to lupus control, while LPS-stimulated production of macrophage IL-10, Con A-stimulated production of splenic IL-10 and, PGE2-reduced production of splenic IFN-γ enhanced. Therefore, these findings suggest that baicalin may protect from autoimmunity and disease activity in lupus via modulatory effect of proinflammatory cytokine overproduction and Th cytokine imbalance.
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KEYWORD
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baicalin, lupus, TNF-α, IL-6, IL-10, IFN-γ
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